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Biophys J, December 2002, p. 2981-2986, Vol. 83, No. 6

Residual Charge Interactions in Unfolded Staphylococcal Nuclease Can Be Explained by the Gaussian-Chain Model

Huan-Xiang Zhou

Department of Physics, Drexel University, Philadelphia, Pennsylvania 19104, USA

The discrepancy of the pH dependence of the unfolding free energy for staphylococcal nuclease from what is expected from an idealized model for the unfolded state is accounted for by the recently developed Gaussian-chain model. Residual electrostatic effects in the unfolded state are attributed to nonspecific interactions dominated by charges close along the sequence. The dominance of nonspecific local interactions appears to be supported by some experimental evidence.

Biophys J, December 2002, p. 2981-2986, Vol. 83, No. 6
© 2002 by the Biophysical Society   0006-3495/02/12/2981/06  $2.00


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