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Buffers and Oscillations in Intracellular Ca²⁺ Dynamics

Hahn Meitner Institute, Glienicker Str. 100, 14109 Berlin, Germany

Correspondence: Address reprint requests to M. Falcke, Hahn Meitner Institute, Glienicker Str. 100, 14109 Berlin, Germany. E-mail: falcke{at}hmi.de.

I model the behavior of intracellular Ca²⁺ release with high buffer concentrations. The model uses a spatially discrete array of channel clusters. The channel subunit dynamics is a stochastic representation of the DeYoung-Keizer model. The calculations show that the concentration profile of fast buffer around an open channel is more localized than that of slow buffers. Slow buffers allow for release of larger amounts of Ca²⁺ from the endoplasmic reticulum and hence bind more Ca²⁺ than fast buffers with the same dissociation constant and concentration. I find oscillation-like behavior for high slow buffer concentration and low Ca²⁺ content of the endoplasmic reticulum. High concentration of slow buffer leads to oscillation-like behavior by repetitive wave nucleation for high Ca²⁺ content of the endoplasmic reticulum. Localization of Ca²⁺ release by slow buffer, as used in experiments, can be reproduced by the modeling approach.

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