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On the Role of Stochastic Channel Behavior in Intracellular Ca²⁺ Dynamics

Hahn Meitner Institute, Glienicker Str. 100, 14109 Berlin, Germany and Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Str. 38, 01187 Dresden, Germany

Correspondence: Address reprint requests to M. Falcke, Hahn Meitner Institute, Glienicker Str. 100, 14109 Berlin, Germany. Tel.: 49-30-80622627; Fax: 49-30-80622098; E-mail: falcke{at}hmi.de.

I present a stochastic model for intracellular Ca²⁺ oscillations. The model starts from stochastic binding and dissociation of Ca²⁺ to binding sites on a single subunit of the IP₃-receptor channel but is capable of simulating large numbers of clusters for many oscillation periods too. I find oscillations with variable periods ranging from 17 s to 120 s and a standard deviation well in the experimentally observed range. Long period oscillations can be perceived as nucleation phenomenon and can be observed for a large variety of single channel dynamics. Their period depends on the geometric characteristics of the cluster array. Short periods are in the range of the time scale of channel dynamics. Both long and short period oscillations occur for parameters with a nonoscillatory deterministic regime.

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