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Direct Radiation Damage Is Confined to a Single Polypeptide in Rabbit Immunoglobulin G

J. H. Miller^*, L. R. Draper and E. S. Kempner^*

^* Laboratory of Physical Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892; and Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045

Correspondence: Address reprint requests to Ellis S. Kempner, E-mail: kempnere{at}exchange.nih.gov.

Frozen rabbit immunoglobulin G was exposed to high-energy electrons. The surviving polypeptide subunits were determined and analyzed by radiation target analysis. Each subunit was independently damaged by radiation whether or not they were bound by disulfide bridges to other subunits, demonstrating that in IgG radiation-deposited energy did not travel across disulfide bonds.

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