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Role of the Dielectric Constants of Membrane Proteins and Channel Water in Ion Permeation

Turgut Batu and Serdar Kuyucak

Department of Theoretical Physics, Research School of Physical Sciences, Australian National University, Canberra, A.C.T. 0200, Australia

Correspondence: Address reprint requests to Dr. Serdar Kuyucak, Dept. of Theoretical Physics, Research School of Physical Sciences, Australian National University, Canberra, A.C.T. 0200, Australia. Tel.: 61-2-6125-2969; Fax: 61-2-6125-4676; E-mail: serdar.kuyucak@anu.edu.au.

Using both analytical solutions obtained from simplified systems and numerical results from more realistic cases, we investigate the role played by the dielectric constant of membrane proteins _p and pore water _w in permeation of ions across channels. We show that the boundary and its curvature are the crucial factors in determining how an ion's potential energy depends on the dielectric constants near an interface. The potential energy of an ion outside a globular protein has a dominant 1/_w dependence, but this becomes 1/_p for an ion inside a cavity. For channels, where the boundaries are in between these two extremes, the situation is more complex. In general, we find that variations in _w have a much larger impact on the potential energy of an ion compared to those in _p. Therefore a better understanding of the effective _w values employed in channel models is desirable. Although the precise value of _p is not a crucial determinant of ion permeation properties, it still needs to be chosen carefully when quantitative comparisons with data are made.

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