help button home button Biophys. J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lees, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lees, S.
Biophysical Journal 85:204-207 (2003)
© 2003 The Biophysical Society

Mineralization of Type I Collagen

Sidney Lees

The Forsyth Institute, Boston, Massachusetts

Correspondence: Address reprint requests to Sidney Lees, The Forsyth Institute, 140 The Fenway, Boston, MA 02115.

It was previously found that the lateral spacing of the collagen molecules in wet mineralized tissues is exactly proportional to the inverse wet density. Several properties were investigated and the same type of relationship was observed each time. A possible explanation is offered. It is hypothesized that mineral is deposited initially in the extrafibrillar space so as to isolate the fibrils. Further deposition reduces the net free fibril volume thereby decreasing the spacing between collagen molecules. The linear relationship is derived from density considerations together with limitations on the collagen packing structure described as the generalized packing model. Three experimental situations were studied: lateral spacing wet tissue versus density; lateral spacing dry tissue versus density; and lateral spacing versus water content. The observed variations of the spacing can be attributed to a structure where the mass of the tissue remains constant but the volume decreases linearly with increasing mineral content.




This article has been cited by other articles:


Home page
 Biophys. JHome page
I. E. Chesnick, J. T. Mason, A. A. Giuseppetti, N. Eidelman, and K. Potter
Magnetic Resonance Microscopy of Collagen Mineralization
Biophys. J., August 15, 2008; 95(4): 2017 - 2026.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
S. Nikolov and D. Raabe
Hierarchical Modeling of the Elastic Properties of Bone at Submicron Scales: The Role of Extrafibrillar Mineralization
Biophys. J., June 1, 2008; 94(11): 4220 - 4232.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. J. Buehler
Nature designs tough collagen: Explaining the nanostructure of collagen fibrils
PNAS, August 15, 2006; 103(33): 12285 - 12290.
[Abstract] [Full Text] [PDF]

Home page
 Reviews in Mineralogy and GeochemistryHome page
A. Veis and A. Veis
Mineralization in Organic Matrix Frameworks
Reviews in Mineralogy and Geochemistry, January 1, 2003; 54(1): 249 - 289.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2003 by the Biophysical Society.