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Originally published as Biophys J. BioFAST on September 17, 2004.
doi:10.1529/biophysj.104.047373
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Biophysical Journal 87:3679-3689 (2004)
© 2004 The Biophysical Society

Kinetics of Filament Bundling with Attractive Interactions

Xueping Yu and A. E. Carlsson

Physics Department, Washington University, St. Louis, Missouri

Correspondence: Address reprint requests to Xueping Yu, Washington University, Dept. of Physics, Campus Box 1105, One Brookings Dr., St. Louis, MO 63130. Tel.: 314-935-5739; E-mail: xyu{at}artsci.wustl.edu.

We study the kinetics of filament bundling by variable time-step Brownian-dynamics simulations employing a simplified attractive potential based on earlier atomic-level calculations for actin filaments. Our results show that collisions often cluster in time, due to memory in the random walk. The clustering increases the bundling opportunities. Small-angle collisions and collisions with short center-to-center distance are more likely to lead to bundling. Increasing the monomer-monomer attraction decreases the bundling time to a diffusional limit, which is determined by the capture cross-section and diffusion coefficients. The simulations clearly show that the bundling process consists of two sequential phases: rotation, by which two filaments align parallel to each other; and sliding, by which they maximize their contact length. Whether two filaments bundle or not is determined by the competition between rotation to a parallel state and escape. Increasing the rotational diffusion coefficient and attraction enhances rotation; decreasing attraction and increasing the translational diffusion coefficients enhance escape. Because of several competing effects, the filament length only affects the bundling time weakly.




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L. Yang, D. Sept, and A. E. Carlsson
Energetics and Dynamics of Constrained Actin Filament Bundling
Biophys. J., June 15, 2006; 90(12): 4295 - 4304.
[Abstract] [Full Text] [PDF]


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