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Optimizing Transport of Metabolites through Large Channels: Molecular Sieves with and without Binding

Alexander M. Berezhkovskii ^* and Sergey M. Bezrukov 

^* Mathematical and Statistical Computing Laboratory, Division of Bioscience, Center for Information Technology, and Laboratory of Physical and Structural Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892

Correspondence: Address reprint requests and inquiries to Sergey M. Bezrukov, Tel.: 301-402-4701; Fax: 301-496-2172; E-mail: bezrukov{at}helix.nih.gov.

Using a diffusion model of molecules moving through a pore, we rationalize why biological channels have an affinity for the molecules they have evolved to translocate.

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