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The Kinetics of Phase Separation in Asymmetric Membranes

Elizabeth J. Wallace ^* , Nigel M. Hooper ^* and Peter D. Olmsted 

^* School of Biochemistry & Microbiology, Leeds Institute of Genetics, Health and Therapeutics, and School of Physics & Astronomy, University of Leeds, Leeds LS2 9JT, United Kingdom

Correspondence: Address reprint requests to Peter D. Olmsted, Tel.: 44-113-343-3830; E-mail: p.d.olmsted{at}leeds.ac.uk.

Phase separation in a model asymmetric membrane is studied using Monte Carlo techniques. The membrane comprises two species of particles, which mimic different lipids in lipid bilayers and separately possess either zero or non-zero spontaneous curvatures. We study the influence of phase separation on membrane shape and the influence of the coupling of composition and height dynamics on phase separation and domain growth, via both the degree of shape asymmetry and relative kinetic coefficients for height relaxation.

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