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Membrane on a Chip: A Functional Tethered Lipid Bilayer Membrane on Silicon Oxide Surfaces

Vladimir Atanasov ^*, Nikolaus Knorr ^*, Randolph S. Duran , Sven Ingebrandt , Andreas Offenhäusser , Wolfgang Knoll ^* and Ingo Köper ^*

^* Max Planck Institute for Polymer Research, 55128 Mainz, Germany; Department of Chemistry, University of Florida, Gainesville, Florida 32611; and Research Center Jülich, 52425 Jülich, Germany

Correspondence: Address reprint requests to Dr. Ingo Köper, E-mail: ingo.koeper{at}mpip-mainz.mpg.de.

Tethered membranes have been proven during recent years to be a powerful and flexible biomimetic platform. We reported in a previous article on the design of a new architecture based on the self-assembly of a thiolipid on ultrasmooth gold substrates, which shows extremely good electrical sealing properties as well as functionality of a bilayer membrane. Here, we describe the synthesis of lipids for a more modular design and the adaptation of the linker part to silane chemistry. We were able to form a functional tethered bilayer lipid membrane with good electrical sealing properties covering a silicon oxide surface. We demonstrate the functional incorporation of the ion carrier valinomycin and of the ion channel gramicidin.

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