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Theoretical Calculations on Hydrogenase Kinetics: Explanation of the Lag Phase and the Enzyme Concentration Dependence of the Activity of Hydrogenase Uptake

Judit sz, Gabriella Bodó, Rui Miguel Mamede Branca and Csaba Bagyinka

Institute of Biophysics, Biological Research Center of the Hungarian Academy of Sciences, H-6701, Szeged, Hungary

Correspondence: Address reprint requests to Csaba Bagyinka, Temesvári krt. 62, Szeged, PO Box 521, H-6701, Hungary. Tel.: 36-62-599605; Fax: 36-62-433133; E-mail: csaba{at}nucleus.szbk.u-szeged.hu.

Two models of the hydrogenase reaction cycle were investigated by means of theoretical calculations and model simulations. The first model is the widely accepted triangular hydrogenase reaction cycle with minor modifications; the second is a modified triangular model, where we have introduced an autocatalytic step into the reaction cycle. Both models include a one-step activation reaction. The theoretical calculations and model simulations corroborate the assumed autocatalytic reaction step concluded from the experimental characteristics of the hydrogenase reaction.

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				J. Osz and C. Bagyinka An Autocatalytic Step in the Reaction Cycle of Hydrogenase from Thiocapsa roseopersicina Can Explain the Special Characteristics of the Enzyme Reaction Biophys. J., September 1, 2005; 89(3): 1984 - 1989. [Abstract] [Full Text] [PDF]