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Originally published as Biophys J. BioFAST on July 22, 2005.
doi:10.1529/biophysj.105.067447
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Biophysical Journal 89:L22-L24 (2005)
© 2005 The Biophysical Society

Terahertz Time-Domain Spectroscopy of Amino Acids and Polypeptides

Kohji Yamamoto *, Keisuke Tominaga * {ddagger}, Hiroaki Sasakawa {dagger}, Atsuo Tamura {dagger}, Hidetoshi Murakami §, Hideyuki Ohtake § and Nobuhiko Sarukura §

* Molecular Photoscience Research Center, and {dagger} Graduate School of Science and Technology, Kobe University, Nada, Kobe, 657-8501 Japan; {ddagger} CREST/JST, Nada, Kobe, 657-8501, Japan; and § Institute for Molecular Science, Myodaiji, Okazaki, 444-8585, Japan

Correspondence: Address reprint requests and inquiries to K. Tominaga, E-mail: tominaga{at}kobe-u.ac.jp.

Frequency-dependent absorption coefficients and refractive indices of amino acids (glycine and L-alanine) and polypeptides (polyglycine and poly-L-alanine) in the wavenumber region from 7 to 55 cm–1 were measured by terahertz time-domain spectroscopy. A vibrational band was observed at 45.5 cm–1 for polyglycine, which was assigned as an interchain mode. The reduced absorption cross sections of the amino acids and polypeptides show power-law behavior. The exponents are different between the monomers and polymers, and those of the two polypeptides suggest that the time dependences of the total dipole moments are similar in the timescale of subpico- to picoseconds.




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