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Biophysical Journal 9: 1323-1328 (1969)
© 1969 the Biophysical Society

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Radiosensitivity of Mammalian Cells

III. Effect of Suboptimal Growth Temperatures on Recovery from Radiation-Induced Division Delay

R. A. Walters, B. R. Burchill and D. F. Petersen

ABSTRACT

We investigated the effect of suboptimal growth temperatures on recovery from radiation-induced division delay in Chinese hamster cells. It was found that no recovery occurred during the time that either log-phase or synchronized populations were incubated at 4°C and that injury sustained at low dose rates was cumulative over a period of 6.2 hr at low temperature. Postirradiation conditions influencing recovery from the induced division delay period are different from those affecting survival, suggesting that biochemical damage leading to division delay may be different from that leading to cell death.






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Copyright © 1969 by the Biophysical Society.