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Modeling the Statistics of Elementary Calcium Release Events

Department of Physics and Astronomy and Quantitative Biology Institute, Ohio University, Athens, Ohio

Correspondence: Address reprint requests to Ghanim Ullah, Dept. of Physics and Astronomy, Ohio University, Athens, OH 45701. Tel.: 740-593-9671; Fax: 740-593-0433; E-mail: ghanimul{at}helios.phy.ohiou.edu.

Elementary Ca²⁺ signals, such as "Ca²⁺ puffs", which arise from the release of Ca²⁺ from endoplasmic reticulum through small clusters of inositol 1,4,5-trisphosphate receptors, are the building blocks for intracellular Ca²⁺ signaling. The small number of release channels involved during a Ca²⁺ puff renders the puffs stochastic, with distributed amplitudes, durations, and frequency, well characterized experimentally. We present a stochastic model that accurately describes simultaneously the statistical properties of the duration, amplitudes, frequencies, and spatial spread with a single set of parameters.

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