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A Steady-State Electrochemical Model of Vascular Smooth Muscle Cells

AU-KBC Research Centre, MIT Campus of Anna University, Chromepet, Chennai, India 600044

Correspondence: Address reprint requests to S. V. Ramanan, Tel.: 91-44-223-4885; Fax: 91-44-2-223-1034; E-mail: ramanan{at}au-kbc.org.

A model of the steady-state electrochemical response of vascular smooth muscle cells to external stimuli is presented, which accounts for K, Na, and Ca fluxes. The results of the model are broadly in accordance with experimental data 1), at various transmural pressures; 2), with channel and pump blockade; and 3), under manipulation of external ionic concentrations. The model exhibits dual stable states which sometimes coexist, and abrupt transitions between these states may account for nongraded responses in arteries as external potassium or pressure is varied. The simulations suggest that changes in the intracellular sodium concentration ([Na]_i) often accompany smooth muscle responses. For example, [Na]_i values vary threefold over the range of pressures from 10 to 100 mmHg.