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Screened Nonbonded Interactions in Native Proteins Manipulate Optimal Paths for Robust Residue Communication

Faculty of Engineering and Natural Sciences, Sabanci University, 34956 Istanbul, Turkey

Correspondence: Address reprint requests to Canan Atilgan, E-mail: canan{at}sabanciuniv.edu.

A protein structure is represented as a network of residues whereby edges are determined by intramolecular contacts. We introduce inhomogeneity into these networks by assigning each edge a weight that is determined by amino acid pair potentials. Two methodologies are utilized to calculate the average path lengths (APLs) between pairs: to minimize i), the maximum weight in the strong APL, and ii), the total weight in the weak APL. We systematically screen edges that have higher than a cutoff potential and calculate the shortest APLs in these reduced networks, while keeping chain connectivity. Therefore, perturbations introduced at a selected region of the residue network propagate to remote regions only along the nonscreened edges that retain their ability to disseminate the perturbation. The shortest APLs computed from the reduced homogeneous networks with only the strongest few nonbonded pairs closely reproduce the strong APLs from the weighted networks. The rate of change in the APL in the reduced residue network as compared to its randomly connected counterpart remains constant until a lower bound. Upon further link removal, this property shows an abrupt increase toward a random coil behavior. Under different perturbation scenarios, diverse optimal paths emerge for robust residue communication.