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Originally published as Biophys J. BioFAST on May 11, 2007.
doi:10.1529/biophysj.106.094482
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Biophysical Journal 93:1580-1590 (2007)
© 2007 The Biophysical Society

Effects of Monovalent Anions of the Hofmeister Series on DPPC Lipid Bilayers Part I: Swelling and In-Plane Equations of State

A. Aroti *, E. Leontidis *, M. Dubois {dagger} and T. Zemb {dagger}

* Department of Chemistry, University of Cyprus, Nicosia, Cyprus; and {dagger} Laboratoire Interdisciplinaire sur l'Organisation Nanomé trique et Supramolé culaire at Département de Recherche sur l'État Condensé, les Atomes, et les Molécules Service de Chimie Moléculaire at Commissariat à l'Energie Atomique, Saclay, F91191 Gif sur Yvette, France

Correspondence: Address reprint requests to E. Leontidis, E-mail: psleon{at}ucy.ac.cy.

Aiming to improve understanding of the mechanisms behind specific anion effects in biological systems we have studied the effects of sodium salts of simple monovalent anions belonging to the Hofmeister series on the bilayers of the zwitterionic lipid 1,2-dipalmitoyl-sn-glycero-3-phosphocholine using small-angle x-ray scattering and the osmotic stress technique. NaCl, NaBr, NaNO3, NaI, and NaSCN were used in this investigation. The electrolytes were found to swell the bilayers and to increase the area per lipid headgroup at each value of the osmotic pressure, suggesting the association of anions with the bilayer-lipid interfaces. The effects follow the Hofmeister series with SCN– inducing the most pronounced changes. "Ion competition" experiments with mixed NaI/NaCl solutions at total salinity 0.1 and 0.5 M revealed that the effect of ions on the lipid equation-of-state is roughly linear at low concentrations, but strongly nonlinear at high concentrations. The experimental results are fitted in a companion article to provide "binding" or "partitioning" constants of anions in the lipid bilayers.




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E. Leontidis, A. Aroti, L. Belloni, M. Dubois, and T. Zemb
Effects of Monovalent Anions of the Hofmeister Series on DPPC Lipid Bilayers Part II: Modeling the Perpendicular and Lateral Equation-of-State
Biophys. J., September 1, 2007; 93(5): 1591 - 1607.
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