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Sound-Evoked Radial Strain in the Hearing Organ

Karolinska Institutet, Center for Hearing and Communication Research, Departments of Clinical Neuroscience and Otolaryngology, M1, Karolinska University Hospital, SE-171 76 Stockholm, Sweden

Correspondence: Address reprint requests to Dr. Anders Fridberger, M1, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden. Tel.: 46-8-51773274; Fax: 46-8-348546; E-mail: anders.fridberger{at}ki.se.

The hearing organ contains sensory hair cells, which convert sound-evoked vibration into action potentials in the auditory nerve. This process is greatly enhanced by molecular motors that reside within the outer hair cells, but the performance also depends on passive mechanical properties, such as the stiffness, mass, and friction of the structures within the organ of Corti. We used resampled confocal imaging to study the mechanical properties of the low-frequency regions of the cochlea. The data allowed us to estimate an important mechanical parameter, the radial strain, which was found to be 0.1% near the inner hair cells and 0.3% near the third row of outer hair cells during moderate-level sound stimulation. The strain was caused by differences in the motion trajectories of inner and outer hair cells. Motion perpendicular to the reticular lamina was greater at the outer hair cells, but inner hair cells showed greater radial vibration. These differences led to deformation of the reticular lamina, which connects the apex of the outer and inner hair cells. These results are important for understanding how the molecular motors of the outer hair cells can so profoundly affect auditory sensitivity.