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Biophys. J. BioFAST: First Published November 19, 2004. doi:10.1529/biophysj.104.052043
© 2004 by the Biophysical Society.

A more recent version of this article appeared on February 1, 2005.
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CHANNELS, RECEPTORS, AND ELECTRICAL SIGNALING

Rapid intracellular TEA block of the KcsA potassium channel

Esin Kutluay 1, Benoit Roux 1 and Lise Heginbotham 2*

1 Weill Medical College of Cornell University
2 Yale University

* To whom correspondence should be addressed. E-mail: lise.heginbotham{at}yale.edu.

Submitted on August 30, 2004
Revised on October 6, 2004
Accepted on 8 October 2004


  Abstract
Intracellular TEA inhibition was studied at the single channel level in the KcsA potassium channel reconstituted in planar lipid bilayers. TEA acts as a fast blocker (resulting in decreased current amplitude) with an affinity in the 75 mM range even at high bandwidth. Studies over a wide voltage range reveal that TEA block has a complex voltage-dependence that also depends the ionic conditions. These observations are examined in the context of permeation models to extend our understanding of the coupling between permeant ions and TEA blockade.

Key Words: Woodhull model, potassium channel, tetraethylammonium, voltage-dependence




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Copyright © 2004 by the Biophysical Society.