help button home button Biophys. J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Biophys. J. BioFAST: First Published May 27, 2005. doi:10.1529/biophysj.104.055822
© 2005 by the Biophysical Society.

A more recent version of this article appeared on August 1, 2005.
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
biophysj.104.055822v1
89/2/1411    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Author home page(s):
Anne Bernheim-Groswasser
Jacques Prost
Cécile Sykes
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bernheim-Groswasser, A.
Right arrow Articles by Sykes, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bernheim-Groswasser, A.
Right arrow Articles by Sykes, C.

CELL BIOPHYSICS

Mechanism of actin-based motility: a dynamic state diagram

Anne Bernheim-Groswasser 1, Jacques Prost 2 and Cécile Sykes 3*

1 Ben Gurion University
2 INSTITUT Curie/CNRS UMR168
3 Institut Curie/CNRS

* To whom correspondence should be addressed. E-mail: cecile.sykes{at}curie.fr.

Submitted on November 5, 2004
Revised on January 5, 2005
Accepted on 17 May 2005


  Abstract
Cells move by a dynamical reorganization of their cytoskeleton, orchestrated by a cascade of biochemical reactions directed to the membrane. Designed objects or bacteria can hijack this machinery to undergo actin-based propulsion inside cells or in a cell-like medium. These objects can explore the dynamical regimes of actin-based propulsion, and display different regimes of motion, in a continuous or periodic fashion. We show that bead movement can switch from one regime to the other by changing the size of the beads, or the surface concentration of the protein activating actin polymerization. We experimentally obtain the state diagram of the bead dynamics, in which the transitions between the different regimes can be understood by a theoretical approach based on an elastic force opposing a friction force. Moreover, the experimental characteristics of the movement, such as the velocity and the characteristic times of the periodic movement, are predicted by our theoretical analysis.

Key Words: Listeria, actin polymerization, force, motility, periodic motion, saltatory




This article has been cited by other articles:


Home page
 Biophys. JHome page
V. Delatour, E. Helfer, D. Didry, K. H. D. Le, J.-F. Gaucher, M.-F. Carlier, and G. Romet-Lemonne
Arp2/3 Controls the Motile Behavior of N-WASP-Functionalized GUVs and Modulates N-WASP Surface Distribution by Mediating Transient Links with Actin Filaments
Biophys. J., June 15, 2008; 94(12): 4890 - 4905.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
L. Trichet, O. Campas, C. Sykes, and J. Plastino
VASP Governs Actin Dynamics by Modulating Filament Anchoring
Biophys. J., February 1, 2007; 92(3): 1081 - 1089.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
R. B. Dickinson and D. L. Purich
Diffusion Rate Limitations in Actin-Based Propulsion of Hard and Deformable Particles
Biophys. J., August 15, 2006; 91(4): 1548 - 1563.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2005 by the Biophysical Society.