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Biophys. J. BioFAST: First Published December 30, 2004. doi:10.1529/biophysj.104.057588
© 2004 by the Biophysical Society.

A more recent version of this article appeared on March 1, 2005.
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BIOPHYSICAL THEORY AND MODELING

Optimizing Transport of Metabolites through Large Channels: Molecular Sieves with and without Binding

Alexander M. Berezhkovskii 1 and Sergey M. Bezrukov 1*

1 NIH

* To whom correspondence should be addressed. E-mail: bezrukov{at}helix.nih.gov.

Submitted on December 5, 2004
Revised on December 17, 2004
Accepted on 28 December 2004


  Abstract
Using a diffusion model of molecules moving through a pore, we rationalize why biological channels have an affinity for the molecules they have evolved to translocate.

Key Words: Diffusion equation, Large channels, Selectivity




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Copyright © 2004 by the Biophysical Society.