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Biophys. J. BioFAST: First Published June 10, 2005. doi:10.1529/biophysj.105.059246
© 2005 by the Biophysical Society.

A more recent version of this article appeared on September 1, 2005.
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PROTEINS

Theoretical calculations on hydrogenase kinetics: explanation of the lag phase and the enzyme concentration dependence of the activity of hydrogenase uptake

Judit sz 1, Gabriella Bodó 1, Rui M. M. Branca 1 and Csaba Bagyinka 1*

1 Institute of Biophysics, Biological Research Center

* To whom correspondence should be addressed. E-mail: csaba{at}nucleus.szbk.u-szeged.hu.

Submitted on January 8, 2005
Revised on March 23, 2005
Accepted on 11 May 2005


  Abstract
Two models of the hydrogenase reaction cycle were investigated by means of theoretical calculations and model simulations. The first model is the widely accepted triangular hydrogenase reaction cycle with minor modifications; the second is a modified triangular model, where we have introduced an autocatalytic step into the reaction cycle. Both models include a one-step activation reaction. The theoretical calculations and model simulations corroborate the assumed autocatalytic reaction step concluded from the experimental characteristics of the hydrogenase reaction.

Key Words: autocatalytic, enzyme reaction, hydrogen uptake, hydrogenase, kinetic simulation




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J. Osz and C. Bagyinka
An Autocatalytic Step in the Reaction Cycle of Hydrogenase from Thiocapsa roseopersicina Can Explain the Special Characteristics of the Enzyme Reaction
Biophys. J., September 1, 2005; 89(3): 1984 - 1989.
[Abstract] [Full Text] [PDF]


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Copyright © 2005 by the Biophysical Society.