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Biophys. J. BioFAST: First Published June 10, 2005. doi:10.1529/biophysj.105.061150
© 2005 by the Biophysical Society.

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BIOPHYSICAL THEORY AND MODELING

Cell motility as persistent random motion: theories from experiments

David Selmeczi 1, Stephan Mosler 2, Peter H Hagedorn 2, Niels B Larsen 2 and Henrik Flyvbjerg 3*

1 Department of Biological Physics, Eötvös Loránd University
2 Risø National Laboratory
3 Risoe National Laboratory

* To whom correspondence should be addressed. E-mail: henrik.flyvbjerg{at}risoe.dk.

Submitted on February 14, 2005
Revised on March 28, 2005
Accepted on 12 May 2005


  Abstract
Experimental time-series for trajectories of motile cells may contain so much information that a systematic analysis will yield cell-type-specific motility models. Here we demonstrate how, using human keratinocytes and fibroblasts as examples. The two resulting models reflect the cells' different roles in the organism, it seems, and show that a cell has a memory of past velocities. They also suggest how to distinguish quantitatively between various surfaces' compatibility with the two cell types.

Key Words: Cell motility, fibroblasts, keratinocytes, non-linear diffusion, persistent random motion, stochastic model






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Copyright © 2005 by the Biophysical Society.