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Biophys. J. BioFAST: First Published June 10, 2005. doi:10.1529/biophysj.105.062158
© 2005 by the Biophysical Society.

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BIOPHYSICAL THEORY AND MODELING

THE TWO-PATHWAY MODEL FOR THE CATCH-SLIP TRANSITION IN BIOLOGICAL ADHESION

Yuriy Pereverzev 1, Oleg V Prezhdo 1*, Manu Forero 1, Evgeni Sokurenko 1 and Wendy Thomas 1

1 University of Washington

* To whom correspondence should be addressed. E-mail: prezhdo{at}u.washington.edu.

Submitted on March 1, 2005
Revised on April 18, 2005
Accepted on 19 May 2005


  Abstract
Some recently studied biological noncovalent bonds have shown increased lifetime when stretched by mechanical force. In each case these counterintuitive "catch-bonds" have transitioned into ordinary "slip-bonds" that become increasingly shorter lived as the tensile force on the bond is further increased. We describe analytically how these results are supported by a physical model whereby the ligand escapes the receptor binding site via two alternative routes, a catch pathway that is opposed by the applied force and a slip pathway that is promoted by force. The model predicts under what conditions and at what critical force the catch- to slip- transition would be observed, as well as the degree to which the bond lifetime is enhanced at the critical force. The model is applied to four experimentally studied systems taken from the literature, involving the binding of P- and L-selectins to sialyl LewisX oligosaccharide-containing ligands. Good quantitative fit to the experimental data is obtained, both for experiments with a constant force and for experiments where the force increases linearly with time.

Key Words: biological adhesion, catch bond, catch-slip transition, selectin, two-pathway model, unbinding force




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Copyright © 2005 by the Biophysical Society.