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Biophys. J. BioFAST: First Published November 18, 2005. doi:10.1529/biophysj.105.072785
© 2005 by the Biophysical Society.

A more recent version of this article appeared on February 1, 2006.
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BIOPHYSICAL THEORY AND MODELING

Enhancement of diffusion-controlled reaction rates by surface-induced orientational restriction

Ambarish Nag 1 and Aaron Dinner 2*

1 The University of Chicago
2 University of Chicago

* To whom correspondence should be addressed. E-mail: dinner{at}uchicago.edu.

Submitted on August 16, 2005
Revised on October 7, 2005
Accepted on 25 October 2005


  Abstract
We explore the means by which immobilization of a substrate on a surface can increase the rate of a diffusion-controlled enzymatic reaction. The quasichemical approach of Solc and Stockmayer is extended and compared with Brownian dynamics simulations. We use these methods to show that restricting only the orientation of the enzyme by long-range interactions with the surface is sufficient for enhancing catalysis.

Key Words: Brownian dynamics, Michaelis-Menten kinetics, Quasichemical approximation




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Copyright © 2005 by the Biophysical Society.