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Biophys. J. BioFAST: First Published March 2, 2006. doi:10.1529/biophysj.105.073460
© 2006 by the Biophysical Society.

A more recent version of this article appeared on May 15, 2006.
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BIOPHYSICAL THEORY AND MODELING

Modeling the Statistics of Elementary Calcium Release Events

Ghanim Ullah 1* and Peter Jung 1

1 Department of Physics and Astronomy and Quantitative Biology institute, Ohio University

* To whom correspondence should be addressed. E-mail: ghanimul{at}helios.phy.ohiou.edu.

Submitted on August 29, 2005
Revised on November 5, 2005
Accepted on 7 February 2006


  Abstract
Elementary Ca2+ signals, such as 'Ca2+ puffs', which arise from the release of Ca2+ from Endoplasmic Reticulum through small clusters of inositol, 4, 5-trisphosphate receptors, are the building blocks for intracellular Ca2+-signaling. The small number of release channels involved during a Ca2+ puff renders the puffs stochastic with distributed amplitudes, durations and frequency, well characterized experimentally. We present a stochastic model that accurately describes simultaneously the statistical properties of the duration, amplitudes, frequencies, and spatial spread with a single set of parameters.

Key Words: Calcium puffs, Inositol 1,4,5-trisphosphate, Inositol 1,4,5-trisphosphate receptors, Stochastic modeling




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Copyright © 2006 by the Biophysical Society.