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Biophys. J. BioFAST: First Published December 30, 2005. doi:10.1529/biophysj.105.075150
© 2005 by the Biophysical Society.

A more recent version of this article appeared on March 15, 2006.
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MEMBRANES

Sphingomyelin structure influences the lateral diffusion and raft formation in lipid bilayers

Andrey Filippov 1, Greger Orädd 1* and Goran Lindblom 2

1 Umeå University
2 Umeå University

* To whom correspondence should be addressed. E-mail: greger.oradd{at}chem.umu.se.

Submitted on September 27, 2005
Revised on November 2, 2005
Accepted on 12 December 2005


  Abstract
Liquid disordered/liquid ordered two-phase coexistence regions in hydrated bilayers have been investigated for sphingomyelins (SMs) of three different origin: egg, brain and milk with the pulsed field gradient NMR technique for lateral diffusion measurement. It is found that the three SMs have the same diffusional behaviour in bilayers of SM alone but in the multicomponent systems of dioleoylphosphatidylcholine/SM/cholesterol the ability to form domains differs for the three SMs. The two-phase area is more extended for egg SM than for brain SM and no two-phase coexistence is found for milk SM. The differences in behavior are correlated with the homogeneity of the SM hydrocarbon chain compositions, in which egg SM has the most homogeneous and milk SM has the most heterogeneous composition. The results indicate that a crucial element in the domain-forming process is the formation of highly packed bilayers of SM and cholesterol rather than specific interactions between SM and cholesterol.

Key Words: DOPC, brain SM, cholesterol, egg SM, lipid domains, milk SM




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Copyright © 2005 by the Biophysical Society.