help button home button Biophys. J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Biophys. J. BioFAST: First Published April 14, 2006. doi:10.1529/biophysj.105.075747
© 2006 by the Biophysical Society.

A more recent version of this article appeared on July 1, 2006.
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
biophysj.105.075747v1
91/1/151    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Higgins, E. R.
Right arrow Articles by Sneyd, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Higgins, E. R.
Right arrow Articles by Sneyd, J.

BIOPHYSICAL THEORY AND MODELING

A Buffering SERCA Pump in Models of Calcium Dynamics

Erin Rothwell Higgins 1, Mark B. Cannell 2 and James Sneyd 1*

1 The University of Auckland
2 University of Auckland School of Medicine

* To whom correspondence should be addressed. E-mail: sneyd{at}math.auckland.ac.nz.

Submitted on October 11, 2005
Revised on January 20, 2006
Accepted on 29 March 2006


  Abstract
Many cells use oscillations in calcium concentration to transmit messages. The oscillations largely result from an influx of calcium into the cytosol from the endoplasmic reticulum (ER), followed by an efflux of calcium from the cytosol back into the ER. The sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) pump pumps calcium into the ER. It binds calcium on the cytosolic side and releases it on the ER side and in the delay between binding and release, calcium is buffered by the pump. We developed a model of a buffering SERCA pump and investigated whether including this in a model of calcium oscillations has any significant effects. We found that the oscillations produced when using the SERCA pump which does not buffer calcium have a larger amplitude and a slightly smaller period than when using the buffering SERCA pump. We show that the buffering SERCA pump shows adaptation to a stimulus and we demonstrate that using a bidirectional SERCA pump we are able to eliminate futile cycling of calcium between the cytosol and ER when the cell is at rest.

Key Words: Calcium buffering, Calcium oscillations, Modeling




This article has been cited by other articles:


Home page
 Biophys. JHome page
R. A. Faville, A. J. Pullan, K. M Sanders, and N. P. Smith
A Biophysically Based Mathematical Model of Unitary Potential Activity in Interstitial Cells of Cajal
Biophys. J., July 1, 2008; 95(1): 88 - 104.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. D. Powell, E. C. Toescu, J. Collinge, and J. G. R. Jefferys
Alterations in Ca2+-Buffering in Prion-Null Mice: Association with Reduced Afterhyperpolarizations in CA1 Hippocampal Neurons
J. Neurosci., April 9, 2008; 28(15): 3877 - 3886.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
M. R. Maurya and S. Subramaniam
A Kinetic Model for Calcium Dynamics in RAW 264.7 Cells: 1. Mechanisms, Parameters, and Subpopulational Variability
Biophys. J., August 1, 2007; 93(3): 709 - 728.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2006 by the Biophysical Society.