BIOPHYSICAL THEORY AND MODELING |
Dynamics of Learning in Cultured Neuronal Networks with Antagonists of Glutamate Receptors
Yanling Li 1, Wei Zhou 1, Xiangning Li 1, Shaoqun Zeng 1 and Qingming Luo 1*
1 The Key Laboratory of Biomedical Photonics of Ministry of Education
* To whom correspondence should be addressed. E-mail: qluo{at}mail.hust.edu.cn.
Submitted on May 2, 2007
Revised on May 28, 2007
Accepted on 14 August 2007
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Abstract |
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Cognitive dysfunction may result from abnormality of ionotropic glutamate receptors. Although various forms of synaptic plasticity in learning relying on altering of glutamate receptors have been considered, the evidence is insufficient from informatics' view. Dynamics could reflect neuroinformatics' encoding including temporal pattern encoding, spatial pattern encoding and energy distribution. Discovering informatics encoding is fundamental and crucial to understand the working principle of the neural system. In this paper, we analyzed dynamic characteristics of response activities during learning training in cultured hippocampal networks under normal and abnormal conditions of ionotropic glutamate receptors, respectively. The rate, which is one of temporal configurations, was decreased markedly by inhibition of AMPA receptors. Moreover, the energy distribution in different characteristic frequencies was changed markedly by inhibition of AMPA receptors. Spatial configurations, including regularization, correlation and synchrony, were changed significantly by inhibition of NMDA receptors. These results suggest that temporal pattern encoding and energy distribution of response activities in cultured hippocampal neuronal networks during learning training are modulated by AMPA receptors; whereas, spatial pattern encoding of response activities are modulated by NMDA receptors.
Key Words:
AMPA receptor, Dynamics, NMDA receptor, cultured hippocampal networks, energy distribution, spatio-temporal configurations
