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Biophys. J. BioFAST: First Published September 14, 2007. doi:10.1529/biophysj.107.118448
© 2007 by the Biophysical Society.

A more recent version of this article appeared on December 1, 2007.
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BIOPHYSICAL LETTERS

Target-specific and global effectors in gene regulation by microRNA

Erel Levine 1*, Eshel Ben Jacob 2 and Herbert Levine 3

1 University of California at San Diego
2 Tel-Aviv University
3 Univ. California, San Diego

* To whom correspondence should be addressed. E-mail: elevine{at}ucsd.edu.

Submitted on July 27, 2007
Revised on August 29, 2007
Accepted on 7 September 2007


  Abstract
MicroRNAs are responsible for post-transcriptional gene silencing as part of critical cellular pathways and intercellular coordination, for example during embryonic development. Yet, the basic mechanism by which this silencing is accomplished is still not understood. For example, it is not known to what extent and through what process does the suppression of protein accumulation accompany a reduction in mRNA level. Here we present a simple quantitative modeling approach to microRNA mediated silencing. We show how differential responses of the mRNA- and protein levels may be tuned by target-specific parameters and how global effectors may alter this behavior for some - but not all - miRNA targets in the cell.

Key Words: gene regulation, microRNA, modeling




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S. Legewie, D. Dienst, A. Wilde, H. Herzel, and I. M. Axmann
Small RNAs Establish Delays and Temporal Thresholds in Gene Expression
Biophys. J., October 1, 2008; 95(7): 3232 - 3238.
[Abstract] [Full Text] [PDF]


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Copyright © 2007 by the Biophysical Society.