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Mathematical Description of Gene Regulatory Units

Bio-Mimetic Control Research Center, RIKEN, Nagoya, Japan

Correspondence: Address reprint requests to H. Kimura, Bio-Mimetic Control Research Center, RIKEN, Shimo-shidami, Moriyama-ku, Nagoya 463-0003 Japan. Tel.: 81-52-736-5861; Fax: 81-52-736-5862; E-mail: kimura{at}bmc.riken.jp.

Revealing the control mechanisms responsible for the cell's surprisingly well-organized functions should lead directly to a better understanding of how the cell adapts to extraordinarily changing environments. A general framework for describing models that can represent diverse biochemical regulatory functions systematically would help not only systematic interpretation of the various models proposed for certain systems but also further understanding of the general control mechanism and design principles underlying different biological systems. This article presents a unified mathematical framework for describing gene regulatory units. The proposed framework is fairly compatible with the classical control theoretical framework, so it should serve as a connecting bridge between engineering control theory and biological control mechanisms. It should also provide a unified view of different regulatory units and facilitate systematic comparison of different mathematical models proposed in a variety of literature.