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Spontaneous Creation of Macroscopic Flow and Metachronal Waves in an Array of Cilia

Laboratoire Physico-chimie Curie, Institut Curie, Paris, France

Correspondence: Address reprint requests to Boris Guirao, Laboratoire Physico-chimie Curie (UMR 168), Institut Curie, 26 rue d'Ulm, 75248, Paris cedex 05, France. Tel.: 33-1-42-34-64-71; E-mail: boris.guirao{at}m4x.org.

Cells carrying cilia on their surface show many striking features: alignment of cilia in an array, two-phase asymmetric beating for each cilium, and existence of metachronal coordination with a constant phase difference between two adjacent cilia. We give simple theoretical arguments based on hydrodynamic coupling and an internal mechanism of the cilium derived from the behavior of a collection of molecular motors to account qualitatively for these cooperative features. Hydrodynamic interactions can lead to the alignment of an array of cilia. We study the effect of a transverse external flow and obtain a two-phase asymmetrical beating, faster along the flow and slower against the flow, proceeding around an average curved position. We show that an aligned array of cilia is able to spontaneously break the left-right symmetry and to create a global average flow. Metachronal coordination arises as a consequence of the internal mechanism of the cilia and their hydrodynamic couplings, with a wavelength comparable to that found in experiments. It allows the cilia to start beating at a lower adenosine-triphosphate threshold and at a higher frequency than for a single cilium. It also leads to a rather stationary flow, which might be its major advantage.