help button home button Biophys. J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Biophys. J. BioFAST: First Published December 2, 2005. doi:10.1529/biophysj.104.058545
© 2005 by the Biophysical Society.

A more recent version of this article appeared on February 15, 2006.
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
biophysj.104.058545v1
90/4/1147    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Reidl, J.
Right arrow Articles by Eiswirth, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Reidl, J.
Right arrow Articles by Eiswirth, M.

BIOPHYSICAL THEORY AND MODELING

Model of Ca oscillations due to negative feedback in olfactory cilia

Juergen Reidl 1, Peter Borowski 2, Anke Sensse 3, Jens Starke 1*, Martin Zapotocky 2 and Markus Eiswirth 3

1 University of Heidelberg
2 Max Planck Institute for Physics of Complex Systems
3 Fritz-Haber-Institut der MPG

* To whom correspondence should be addressed. E-mail: starke{at}iwr.uni-heidelberg.de.

Submitted on January 18, 2005
Revised on April 21, 2005
Accepted on 6 October 2005


  Abstract
We present a mathematical model for Ca oscillations in the cilia of olfactory sensory neurons. The underlying mechanism is based on direct negative regulation of cyclic nucleotide-gated channels by calcium/calmodulin and does not require any autocatalysis such as calcium-induced calcium release. The model is in quantitative agreement with available experimental data, both with respect to oscillations and to fast adaptation. We give predictions for the ranges of parameters in which oscillations should be observable. Relevance of the model to calcium oscillations in other systems is discussed.

Key Words: Ca oscillations, Hopf bifurcation, differential equations, negative feedback, signal transduction in olfactory cilia, stoichiometric network analysis




This article has been cited by other articles:


Home page
 Chem SensesHome page
S. J. Kleene
The Electrochemical Basis of Odor Transduction in Vertebrate Olfactory Cilia
Chem Senses, August 14, 2008; (2008) bjn048v1.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Physiol.Home page
A. Boccaccio, L. Lagostena, V. Hagen, and A. Menini
Fast Adaptation in Mouse Olfactory Sensory Neurons Does Not Require the Activity of Phosphodiesterase
J. Gen. Physiol., July 31, 2006; 128(2): 171 - 184.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2005 by the Biophysical Society.