Cover picture: Ribbon representation of the five known antifreeze protein (AFP) structures from fish (Type I to III) and insects (spruce budworm and Tenebrio molitor). All AFPs are thought to bind to ice and inhibit its growth by similar methods, yet the folds are quite diverse. The actual binding mechanism remains elusive, but it appears that Type I AFP does not unfold or aggregate before binding to ice. See the article by Graether et al. on p. 1677.