Biophysical Journal 84 1

Cover: Autoinhibition by target minetics in the regulatory domain of skeletal troponin-C (N-sTnC). The structural elements bound to the interaction surface in each conformations are: residues 42-51 of helix-B and of the adjacent linker (upper panel), and a model peptide fragment from TnI comprising residues 117-125 (lower panel). Aromatic groups that mark the binding site are shown in an all-atom representation. Atomic coordinates are from the crystal structure of apo sTnC (Herzberg and James, 1988), and from a model built by analogy to the CaM-kinaseIIa complex (Meador et al., 1993). See the article by Pitici on p. 82.