Biophysical Journal 86 2

Cover: The shape of the model channel and Brownian dynamics simulation system. The atomic detail of the crystal structure of the E. coli channel, EcClC, taken from Dutzler et al. (2002) (top) and our open model of the channel (inset) are shown with the front half of the atoms removed to reveal the pore. The surface of the open pore in gold is superimposed on each diagram. (Bottom) A cylindrical reservoir containing a fixed number of Na⁺ (shown in yellow) and Cl⁻ (green) is attached at each end of the channel for Brownian dynamics simulation. The channel protein is imbedded in a low dielectric region representing the membrane (gold). See article by Corry et al. on p. 846.