Cover picture: A three-dimensional representation of the α-interacting domain (AID) helix of the rabbit CaV1.2 obtained with INSIGHT II, using the human CaV1.2 crystal structure cocrystallized with CaVβ2a (Protein Data Bank: 1T0J.pdb) as a template (see Van Petegem et al., 2004, reference in article). The core of the AID helix appears in white. Hydrophilic residues shown in color (E461 in orange, E462 in yellow, D463 in turquoise, D469 in green, and Q473 in red) are free to interact with other proteins or other cytoplasmic regions of the channel. The hydrophobic residues (Y467, W470, and I471) of the AID helix interacts with the CaVβ2a subunit shown in blue. See the article by Dafi et al. on page 3181.
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Copyright © 2006 by the Biophysical Society.
