Biophysical Journal -- Table of Contents (88 [2])

BIOPHYSICAL LETTERS:

Ali M. Alaouie and Alex I. Smirnov: Cooperativity and Kinetics of Phase Transitions in Nanopore-Confined Bilayers Studied by Differential Scanning Calorimetry
Biophys. J. 2005 88: L11-L13; Published ahead of print on December 30, 2004 as doi:10.1529/biophysj.104.056523. [Abstract] [Full Text] [PDF]

Mark A. Rizzo and David W. Piston: High-Contrast Imaging of Fluorescent Protein FRET by Fluorescence Polarization Microscopy
Biophys. J. 2005 88: L14-L16; Published ahead of print on December 21, 2004 as doi:10.1529/biophysj.104.055442. [Abstract] [Full Text] [PDF]

EDITORIAL:

Dianne McGavin, Bernard Stukenborg, and Mark Witkowski: Color Figures in BJ: RGB versus CMYK
Biophys. J. 2005 88: 761-762. [Full Text] [PDF]

NEW AND NOTABLE:

John van Noort: Unraveling Bacteriorhodopsin
Biophys. J. 2005 88: 763-764; Published ahead of print on December 13, 2004 as doi:10.1529/biophysj.104.056242. [Full Text] [PDF]

BIOPHYSICAL THEORY AND MODELING:

J. Pablo Marquez, Guy M. Genin, George I. Zahalak, and Elliot L. Elson: Thin Bio-Artificial Tissues in Plane Stress: The Relationship between Cell and Tissue Strain, and an Improved Constitutive Model
Biophys. J. 2005 88: 765-777; Published ahead of print on December 13, 2004 as doi:10.1529/biophysj.104.040808. [Abstract] [Full Text] [PDF]

J. Pablo Marquez, Guy M. Genin, George I. Zahalak, and Elliot L. Elson: The Relationship between Cell and Tissue Strain in Three-Dimensional Bio-Artificial Tissues
Biophys. J. 2005 88: 778-789; Published ahead of print on December 13, 2004 as doi:10.1529/biophysj.104.041947. [Abstract] [Full Text] [PDF]

Frauke Gräter, Jianhua Shen, Hualiang Jiang, Mathias Gautel, and Helmut Grubmüller: Mechanically Induced Titin Kinase Activation Studied by Force-Probe Molecular Dynamics Simulations
Biophys. J. 2005 88: 790-804; Published ahead of print on November 5, 2004 as doi:10.1529/biophysj.104.052423. [Abstract] [Full Text] [PDF]

Ryan W. Benz, Francisco Castro-Román, Douglas J. Tobias, and Stephen H. White: Experimental Validation of Molecular Dynamics Simulations of Lipid Bilayers: A New Approach
Biophys. J. 2005 88: 805-817; Published ahead of print on November 8, 2004 as doi:10.1529/biophysj.104.046821. [Abstract] [Full Text] [PDF]

Konrad Hinsen, Nathalie Reuter, Jorge Navaza, David L. Stokes, and Jean-Jacques Lacapère: Normal Mode-Based Fitting of Atomic Structure into Electron Density Maps: Application to Sarcoplasmic Reticulum Ca-ATPase
Biophys. J. 2005 88: 818-827; Published ahead of print on November 12, 2004 as doi:10.1529/biophysj.104.050716. [Abstract] [Full Text] [PDF]

Aleksandra M. Walczak, Masaki Sasai, and Peter G. Wolynes: Self-Consistent Proteomic Field Theory of Stochastic Gene Switches
Biophys. J. 2005 88: 828-850; Published ahead of print on November 12, 2004 as doi:10.1529/biophysj.104.050666. [Abstract] [Full Text] [PDF]

Prashant K. Purohit, Mandar M. Inamdar, Paul D. Grayson, Todd M. Squires, Jané Kondev, and Rob Phillips: Forces during Bacteriophage DNA Packaging and Ejection
Biophys. J. 2005 88: 851-866; Published ahead of print on November 19, 2004 as doi:10.1529/biophysj.104.047134. [Abstract] [Full Text] [PDF]

Kitiyaporn Wittayanarakul, Ornjira Aruksakunwong, Suwipa Saen-oon, Wasun Chantratita, Vudhichai Parasuk, Pornthep Sompornpisut, and Supot Hannongbua: Insights into Saquinavir Resistance in the G48V HIV-1 Protease: Quantum Calculations and Molecular Dynamic Simulations
Biophys. J. 2005 88: 867-879; Published ahead of print on November 12, 2004 as doi:10.1529/biophysj.104.046110. [Abstract] [Full Text] [PDF]

Paul Wiggins and Rob Phillips: Membrane-Protein Interactions in Mechanosensitive Channels
Biophys. J. 2005 88: 880-902; Published ahead of print on November 12, 2004 as doi:10.1529/biophysj.104.047431. [Abstract] [Full Text] [PDF]

Donald J. Jacobs and Sargis Dallakyan: Elucidating Protein Thermodynamics from the Three-Dimensional Structure of the Native State Using Network Rigidity
Biophys. J. 2005 88: 903-915; Published ahead of print on November 12, 2004 as doi:10.1529/biophysj.104.048496. [Abstract] [Full Text] [PDF] [supplemental file]

Veena Pata and Nily Dan: Effect of Membrane Characteristics on Phase Separation and Domain Formation in Cholesterol-Lipid Mixtures
Biophys. J. 2005 88: 916-924; Published ahead of print on November 12, 2004 as doi:10.1529/biophysj.104.052241. [Abstract] [Full Text] [PDF]

Jennifer L. Knight, Vladimir Mekler, Jayanta Mukhopadhyay, Richard H. Ebright, and Ronald M. Levy: Distance-Restrained Docking of Rifampicin and Rifamycin SV to RNA Polymerase Using Systematic FRET Measurements: Developing Benchmarks of Model Quality and Reliability
Biophys. J. 2005 88: 925-938; Published ahead of print on November 12, 2004 as doi:10.1529/biophysj.104.050187. [Abstract] [Full Text] [PDF]

M. F. Lensink, B. Christiaens, J. Vandekerckhove, A. Prochiantz, and M. Rosseneu: Penetratin-Membrane Association: W48/R52/W56 Shield the Peptide from the Aqueous Phase
Biophys. J. 2005 88: 939-952; Published ahead of print on November 12, 2004 as doi:10.1529/biophysj.104.052787. [Abstract] [Full Text] [PDF]

Kai Liu, Zongchao Jia, Guangju Chen, Chenho Tung, and Ruozhuang Liu: Systematic Size Study of an Insect Antifreeze Protein and Its Interaction with Ice
Biophys. J. 2005 88: 953-958. [Abstract] [Full Text] [PDF]

Leonor Saiz and Michael L. Klein: The Transmembrane Domain of the Acetylcholine Receptor: Insights from Simulations on Synthetic Peptide Models
Biophys. J. 2005 88: 959-970; Published ahead of print on November 19, 2004 as doi:10.1529/biophysj.104.049726. [Abstract] [Full Text] [PDF]

Allen P. Minton: Models for Excluded Volume Interaction between an Unfolded Protein and Rigid Macromolecular Cosolutes: Macromolecular Crowding and Protein Stability Revisited
Biophys. J. 2005 88: 971-985; Published ahead of print on December 13, 2004 as doi:10.1529/biophysj.104.050351. [Abstract] [Full Text] [PDF]

Grzegorz Raszewski, Wolfram Saenger, and Thomas Renger: Theory of Optical Spectra of Photosystem II Reaction Centers: Location of the Triplet State and the Identity of the Primary Electron Donor
Biophys. J. 2005 88: 986-998; Published ahead of print on November 19, 2004 as doi:10.1529/biophysj.104.050294. [Abstract] [Full Text] [PDF]

Ganhui Lan and Sean X. Sun: Dynamics of Myosin-V Processivity
Biophys. J. 2005 88: 999-1008; Published ahead of print on November 19, 2004 as doi:10.1529/biophysj.104.047662. [Abstract] [Full Text] [PDF]

Alexander C. Saladino, Yan Xu, and Pei Tang: Homology Modeling and Molecular Dynamics Simulations of Transmembrane Domain Structure of Human Neuronal Nicotinic Acetylcholine Receptor
Biophys. J. 2005 88: 1009-1017; Published ahead of print on December 1, 2004 as doi:10.1529/biophysj.104.053421. [Abstract] [Full Text] [PDF]

CHANNELS, RECEPTORS, AND ELECTRICAL SIGNALING:

Esin Kutluay, Benoît Roux, and Lise Heginbotham: Rapid Intracellular TEA Block of the KcsA Potassium Channel
Biophys. J. 2005 88: 1018-1029; Published ahead of print on November 19, 2004 as doi:10.1529/biophysj.104.052043. [Abstract] [Full Text] [PDF]

Chiu Shuen Hui: Association of the I and I Charge Movement with Calcium Release in Frog Skeletal Muscle
Biophys. J. 2005 88: 1030-1045; Published ahead of print on November 8, 2004 as doi:10.1529/biophysj.104.048215. [Abstract] [Full Text] [PDF]

Huiping Tu, Zhengnan Wang, Elena Nosyreva, Humbert De Smedt, and Ilya Bezprozvanny: Functional Characterization of Mammalian Inositol 1,4,5-Trisphosphate Receptor Isoforms
Biophys. J. 2005 88: 1046-1055; Published ahead of print on November 8, 2004 as doi:10.1529/biophysj.104.049593. [Abstract] [Full Text] [PDF]

Huiping Tu, Zhengnan Wang, and Ilya Bezprozvanny: Modulation of Mammalian Inositol 1,4,5-Trisphosphate Receptor Isoforms by Calcium: A Role of Calcium Sensor Region
Biophys. J. 2005 88: 1056-1069; Published ahead of print on November 5, 2004 as doi:10.1529/biophysj.104.049601. [Abstract] [Full Text] [PDF]

Devaki A. Kelkar and Amitabha Chattopadhyay: Effect of Graded Hydration on the Dynamics of an Ion Channel Peptide: A Fluorescence Approach
Biophys. J. 2005 88: 1070-1080; Published ahead of print on November 12, 2004 as doi:10.1529/biophysj.104.051490. [Abstract] [Full Text] [PDF]

MEMBRANES:

F. Natali, C. Castellano, D. Pozzi, and A. Congiu Castellano: Dynamic Properties of an Oriented Lipid/DNA Complex Studied by Neutron Scattering
Biophys. J. 2005 88: 1081-1090; Published ahead of print on November 12, 2004 as doi:10.1529/biophysj.104.042788. [Abstract] [Full Text] [PDF]

Krzysztof Murzyn, Tomasz Róg, and Marta Pasenkiewicz-Gierula: Phosphatidylethanolamine-Phosphatidylglycerol Bilayer as a Model of the Inner Bacterial Membrane
Biophys. J. 2005 88: 1091-1103; Published ahead of print on November 19, 2004 as doi:10.1529/biophysj.104.048835. [Abstract] [Full Text] [PDF]

Jonggu Jeon and Gregory A. Voth: The Dynamic Stress Responses to Area Change in Planar Lipid Bilayer Membranes
Biophys. J. 2005 88: 1104-1119; Published ahead of print on November 12, 2004 as doi:10.1529/biophysj.104.052183. [Abstract] [Full Text] [PDF]

Peter I. Kuzmin, Sergey A. Akimov, Yuri A. Chizmadzhev, Joshua Zimmerberg, and Fredric S. Cohen: Line Tension and Interaction Energies of Membrane Rafts Calculated from Lipid Splay and Tilt
Biophys. J. 2005 88: 1120-1133; Published ahead of print on November 12, 2004 as doi:10.1529/biophysj.104.048223. [Abstract] [Full Text] [PDF]

Mark K. Doeven, Joost H. A. Folgering, Victor Krasnikov, Eric R. Geertsma, Geert van den Bogaart, and Bert Poolman: Distribution, Lateral Mobility and Function of Membrane Proteins Incorporated into Giant Unilamellar Vesicles
Biophys. J. 2005 88: 1134-1142; Published ahead of print on December 1, 2004 as doi:10.1529/biophysj.104.053413. [Abstract] [Full Text] [PDF]

Karin A. Riske and Rumiana Dimova: Electro-Deformation and Poration of Giant Vesicles Viewed with High Temporal Resolution
Biophys. J. 2005 88: 1143-1155; Published ahead of print on December 13, 2004 as doi:10.1529/biophysj.104.050310. [Abstract] [Full Text] [PDF] [supplemental files]

MUSCLE AND CONTRACTILITY:

J. Balogh, Z. Li, D. Paulin, and A. Arner: Desmin Filaments Influence Myofilament Spacing and Lateral Compliance of Slow Skeletal Muscle Fibers
Biophys. J. 2005 88: 1156-1165; Published ahead of print on November 12, 2004 as doi:10.1529/biophysj.104.042630. [Abstract] [Full Text] [PDF]

NUCLEIC ACIDS:

Wei Ge, Bohdan Schneider, and Wilma K. Olson: Knowledge-Based Elastic Potentials for Docking Drugs or Proteins with Nucleic Acids
Biophys. J. 2005 88: 1166-1190; Published ahead of print on October 22, 2004 as doi:10.1529/biophysj.104.043612. [Abstract] [Full Text] [PDF] [supplemental file]

Yongjun Lu, Brock D. Weers, and Nancy C. Stellwagen: Intrinsic Curvature in the VP1 Gene of SV40: Comparison of Solution and Gel Results
Biophys. J. 2005 88: 1191-1206; Published ahead of print on November 19, 2004 as doi:10.1529/biophysj.104.039834. [Abstract] [Full Text] [PDF]

Vendula Bursova, Jana Kasparkova, Ctirad Hofr, and Viktor Brabec: Effects of Monofunctional Adducts of Platinum(II) Complexes on Thermodynamic Stability and Energetics of DNA Duplexes
Biophys. J. 2005 88: 1207-1214; Published ahead of print on December 1, 2004 as doi:10.1529/biophysj.104.051771. [Abstract] [Full Text] [PDF] [supplemental file]

PHOTOBIOPHYSICS:

Masayuki Iwamoto, Yuki Sudo, Kazumi Shimono, Tsunehisa Araiso, and Naoki Kamo: Correlation of the O-Intermediate Rate with the pK_a of Asp-75 in the Dark, the Counterion of the Schiff Base of Pharaonis Phoborhodopsin (Sensory Rhodopsin II)
Biophys. J. 2005 88: 1215-1223; Published ahead of print on November 8, 2004 as doi:10.1529/biophysj.104.045583. [Abstract] [Full Text] [PDF]

Marion Peter, Simon M. Ameer-Beg, Michael K. Y. Hughes, Melanie D. Keppler, Søren Prag, Mark Marsh, Borivoj Vojnovic, and Tony Ng: Multiphoton-FLIM Quantification of the EGFP-mRFP1 FRET Pair for Localization of Membrane Receptor-Kinase Interactions
Biophys. J. 2005 88: 1224-1237; Published ahead of print on November 5, 2004 as doi:10.1529/biophysj.104.050153. [Abstract] [Full Text] [PDF]

Naranbaatar Dashdorj, Wu Xu, Rachel O. Cohen, John H. Golbeck, and Sergei Savikhin: Asymmetric Electron Transfer in Cyanobacterial Photosystem I: Charge Separation and Secondary Electron Transfer Dynamics of Mutations Near the Primary Electron Acceptor A₀
Biophys. J. 2005 88: 1238-1249; Published ahead of print on November 12, 2004 as doi:10.1529/biophysj.104.050963. [Abstract] [Full Text] [PDF]

PROTEINS:

Catherine Tetreau, Liliane Mouawad, Samuel Murail, Patricia Duchambon, Yves Blouquit, and Daniel Lavalette: Disentangling Ligand Migration and Heme Pocket Relaxation in Cytochrome P450_cam
Biophys. J. 2005 88: 1250-1263; Published ahead of print on October 15, 2004 as doi:10.1529/biophysj.104.050104. [Abstract] [Full Text] [PDF]

Cui-Yan Tan, Chun-He Xu, Jun Wong, Jian-Ren Shen, Shinsuke Sakuma, Yasusi Yamamoto, Reinhard Lange, Claude Balny, and Kang-Cheng Ruan: Pressure Equilibrium and Jump Study on Unfolding of 23-kDa Protein from Spinach Photosystem II
Biophys. J. 2005 88: 1264-1275; Published ahead of print on November 5, 2004 as doi:10.1529/biophysj.104.050435. [Abstract] [Full Text] [PDF]

Dessislava Georgieva, Daniel Schwark, Peter Nikolov, Krassimira Idakieva, Katja Parvanova, Karsten Dierks, Nicolay Genov, and Christian Betzel: Conformational States of the Rapana thomasiana Hemocyanin and Its Substructures Studied by Dynamic Light Scattering and Time-Resolved Fluorescence Spectroscopy
Biophys. J. 2005 88: 1276-1282; Published ahead of print on November 8, 2004 as doi:10.1529/biophysj.104.048066. [Abstract] [Full Text] [PDF]

Jaume Torres, Jifeng Wang, Krupakar Parthasarathy, and Ding Xiang Liu: The Transmembrane Oligomers of Coronavirus Protein E
Biophys. J. 2005 88: 1283-1290. [Abstract] [Full Text] [PDF]

Alejandra Leo-Macias, Pedro Lopez-Romero, Dmitry Lupyan, Daniel Zerbino, and Angel R. Ortiz: An Analysis of Core Deformations in Protein Superfamilies
Biophys. J. 2005 88: 1291-1299; Published ahead of print on November 12, 2004 as doi:10.1529/biophysj.104.052449. [Abstract] [Full Text] [PDF] [supplemental file]

Sharmistha Sinha, Nivedita Mitra, Gyanendra Kumar, Kanika Bajaj, and Avadhesha Surolia: Unfolding Studies on Soybean Agglutinin and Concanavalin A Tetramers: A Comparative Account
Biophys. J. 2005 88: 1300-1310; Published ahead of print on November 12, 2004 as doi:10.1529/biophysj.104.051052. [Abstract] [Full Text] [PDF]

Luis A. Campos, Santiago Cuesta-López, Jon López-Llano, Fernando Falo, and Javier Sancho: A Double-Deletion Method to Quantifying Incremental Binding Energies in Proteins from Experiment: Example of a Destabilizing Hydrogen Bonding Pair
Biophys. J. 2005 88: 1311-1321; Published ahead of print on November 19, 2004 as doi:10.1529/biophysj.104.050203. [Abstract] [Full Text] [PDF]

Ananthakrishnan Sethuraman and Georges Belfort: Protein Structural Perturbation and Aggregation on Homogeneous Surfaces
Biophys. J. 2005 88: 1322-1333; Published ahead of print on November 12, 2004 as doi:10.1529/biophysj.104.051797. [Abstract] [Full Text] [PDF]

Alessandro Barducci, Riccardo Chelli, Piero Procacci, and Vincenzo Schettino: Misfolding Pathways of the Prion Protein Probed by Molecular Dynamics Simulations
Biophys. J. 2005 88: 1334-1343; Published ahead of print on November 19, 2004 as doi:10.1529/biophysj.104.049882. [Abstract] [Full Text] [PDF]

Ralf Jansen, Wojciech Dzwolak, and Roland Winter: Amyloidogenic Self-Assembly of Insulin Aggregates Probed by High Resolution Atomic Force Microscopy
Biophys. J. 2005 88: 1344-1353; Published ahead of print on December 1, 2004 as doi:10.1529/biophysj.104.048843. [Abstract] [Full Text] [PDF]

Péter Bagossi, Gábor Horváth, György Vereb, János Szöllösi, and József Tözsér: Molecular Modeling of Nearly Full-Length ErbB2 Receptor
Biophys. J. 2005 88: 1354-1363; Published ahead of print on December 13, 2004 as doi:10.1529/biophysj.104.046003. [Abstract] [Full Text] [PDF]

SUPRAMOLECULAR ASSEMBLIES:

Marta de Frutos, Lucienne Letellier, and Eric Raspaud: DNA Ejection from Bacteriophage T5: Analysis of the Kinetics and Energetics
Biophys. J. 2005 88: 1364-1370; Published ahead of print on November 12, 2004 as doi:10.1529/biophysj.104.048785. [Abstract] [Full Text] [PDF]

Garrott W. Christoph, James Hofrichter, and William A. Eaton: Understanding the Shape of Sickled Red Cells
Biophys. J. 2005 88: 1371-1376; Published ahead of print on November 12, 2004 as doi:10.1529/biophysj.104.051250. [Abstract] [Full Text] [PDF]

SPECTROSCOPY, IMAGING, OTHER TECHNIQUES:

Rebecca M. Williams, Warren R. Zipfel, and Watt W. Webb: Interpreting Second-Harmonic Generation Images of Collagen I Fibrils
Biophys. J. 2005 88: 1377-1386; Published ahead of print on November 8, 2004 as doi:10.1529/biophysj.104.047308. [Abstract] [Full Text] [PDF]

Jeffrey R. Kuhn and Thomas D. Pollard: Real-Time Measurements of Actin Filament Polymerization by Total Internal Reflection Fluorescence Microscopy
Biophys. J. 2005 88: 1387-1402; Published ahead of print on November 19, 2004 as doi:10.1529/biophysj.104.047399. [Abstract] [Full Text] [PDF]

James H. Werner, Hong Cai, Richard A. Keller, and Peter M. Goodwin: Exonuclease I Hydrolyzes DNA with a Distribution of Rates
Biophys. J. 2005 88: 1403-1412; Published ahead of print on November 12, 2004 as doi:10.1529/biophysj.104.044255. [Abstract] [Full Text] [PDF]

Krishnananda Chattopadhyay, Saveez Saffarian, Elliot L. Elson, and Carl Frieden: Measuring Unfolding of Proteins in the Presence of Denaturant Using Fluorescence Correlation Spectroscopy
Biophys. J. 2005 88: 1413-1422; Published ahead of print on November 19, 2004 as doi:10.1529/biophysj.104.053199. [Abstract] [Full Text] [PDF]

Harald Janovjak, Daniel J. Müller, and Andrew D. L. Humphris: Molecular Force Modulation Spectroscopy Revealing the Dynamic Response of Single Bacteriorhodopsins
Biophys. J. 2005 88: 1423-1431; Published ahead of print on December 1, 2004 as doi:10.1529/biophysj.104.052746. [Abstract] [Full Text] [PDF]

CELL BIOPHYSICS:

Nipa A. Mody, Oleg Lomakin, Teresa A. Doggett, Thomas G. Diacovo, and Michael R. King: Mechanics of Transient Platelet Adhesion to von Willebrand Factor under Flow
Biophys. J. 2005 88: 1432-1443; Published ahead of print on November 8, 2004 as doi:10.1529/biophysj.104.047001. [Abstract] [Full Text] [PDF]

Lisbeth C. Robinson and Jonathan S. Marchant: Improved "Optical Highlighter" Probes Derived from Discosoma Red Fluorescent Protein
Biophys. J. 2005 88: 1444-1457; Published ahead of print on November 19, 2004 as doi:10.1529/biophysj.104.045617. [Abstract] [Full Text] [PDF] [supplemental files]

Bryan T. Marshall, Krishna K. Sarangapani, Jizhong Lou, Rodger P. McEver, and Cheng Zhu: Force History Dependence of Receptor-Ligand Dissociation
Biophys. J. 2005 88: 1458-1466; Published ahead of print on November 19, 2004 as doi:10.1529/biophysj.104.050567. [Abstract] [Full Text] [PDF]

François Waharte, Claire M. Brown, Sylvie Coscoy, Evelyne Coudrier, and François Amblard: A Two-Photon FRAP Analysis of the Cytoskeleton Dynamics in the Microvilli of Intestinal Cells
Biophys. J. 2005 88: 1467-1478; Published ahead of print on December 13, 2004 as doi:10.1529/biophysj.104.049619. [Abstract] [Full Text] [PDF]

Brian D. Harms, Gina M. Bassi, Alan Rick Horwitz, and Douglas A. Lauffenburger: Directional Persistence of EGF-Induced Cell Migration Is Associated with Stabilization of Lamellipodial Protrusions
Biophys. J. 2005 88: 1479-1488. [Abstract] [Full Text] [PDF]

OTHER:

Shizhuo Yin, Xueqian Zhang, Chun Zhan, Juntao Wu, Jinchao Xu, and Joseph Cheung: Measuring Single Cardiac Myocyte Contractile Force via Moving a Magnetic Bead
Biophys. J. 2005 88: 1489-1495; Published ahead of print on November 8, 2004 as doi:10.1529/biophysj.104.048157. [Abstract] [Full Text] [PDF]

Michael Greenberg, Karl Canter, Inga Mahler, and Adam Tornheim: Observation of Magnetoreceptive Behavior in a Multicellular Magnetotactic Prokaryote in Higher than Geomagnetic Fields
Biophys. J. 2005 88: 1496-1499; Published ahead of print on November 19, 2004 as doi:10.1529/biophysj.104.047068. [Abstract] [Full Text] [PDF] [supplemental file]