Cover picture: Principal motions from the essential dynamics analysis relative to MNEI (orange ribbon representation) and G16A (green ribbon representation). First, second, and third components for MNEI are shown in panels A–C, whereas in D–F the same components for G16A are shown. The principal motions are drawn in blue with the porcupine representation; the cones’ directions render the global protein motions. See the article by De Simone et al. on page 3052.