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Edward Egelman (Section I Expertise)
Department of Biochemistry/Molecular Genetics
University of Virginia Health Science Center
(Research information for most of the Editorial Board Members is listed in the format: Research Area//Techniques)
Edward Egelman, Editor in Chief - Macromolecular complexes, actin, helical polymers, DNA recombination // electron microscopy, image analysis, three-dimensional reconstruction.
SECTION I: PROTEINS, NUCLEIC ACIDS, SUPRAMOLECULAR ASSEMBLIES
Kathleen Hall, Associate Editor - RNA structure, function; RNA: protein structure and thermodynamics; RNA and protein dynamics // NMR, molecular dynamics simulations, fluorescence spectroscopy.
Doug Barrick - Protein folding, biothermodynamics, protein-protein interactions, Notch signaling, repeat-proteins, physical chemistry of proteins//CD, fluorescence, Calorimetry, stopped-flow, protein engineering, analysis of conformational equilibria, analysis of binding equilibria.
Sam Butcher - Pre-mRNA splicing, spliceosomal RNA, translational frameshifting, RNA structure, RNA thermodynamics, RNA binding proteins, ribozymes, riboswitches // NMR, restrained molecular dynamics, UV spectrophotometry, calorimetry, gel filtration chromatography
J. Brad Chaires - Nucleic Acids, Ligand Binding, Chromatin, DNA, RNA, Thermodynamics, Protein binding reactions, Allostery, Macromolecular association reactions // Calorimetry (DSC, ITC), Spectrophotometric titrations, Nonlinear least squares fitting of data, Multicomponent analysis (singular value decompositon, principal component analysis), Dialysis methods, Stopped-flow kinetics, Relaxation kinetic methods.
Jane Clarke - Protein folding, protein stability, mechanical properties of proteins // Thermodynamics, kinetics, phi-value analysis, atomic force microscopy.
Elena Conti - Nuclear transport, RNA metabolism // x-ray crystallography.
Ron Elber - Protein structure and dynamics, conformational transitions, oxygen transport: myoglobin and hemoglobin, protein folding, ion channels // Computer simulations, Molecular Dynamics, Path Integrals, Stochastic Dynamics, Reaction paths.
Angel Garcia - Protein folding, nucleic acids, molecular biophysics, protein structure and dynamics hydrophobic effect, biomolecular hydration, biomolecular simulations, statistical mechanics, thermodynamics, theory // molecular dynamics simulations, molecular modeling, computation.
Bertrand E. Garcia-Moreno - Protein thermodynamics, electrostatics, protein folding, structure-based energy calculations and pKa calculations, hydration, calorimetry, solution thermodynamics, recognition and binding, stability, protein physical chemistry.
Leemor Joshua-Tor - Protein-nucleic acid interactions, RNAi, gene silencing, replication // Macromolecular crystallography, biochemistry.
David Millar - Protein-nucleic acid interactions, DNA replication and recombination, RNA folding//time-resolved and single-molecule fluorescence spectroscopy, FRET, rapid kinetics.
Marcia Newcomer - Protein structure and function, 3-D domain swapping, protein-hydrophobic ligand interaction, retinoids // X-ray crystallography, kinetics.
Ruth Nussinov - Protein-protein interactions, amyloid conformations, protein structure, function and dynamics, Systems Biology, RNA structure, RNA-protein interactions, protein folding // algorithms for protein docking, structural comparisons, molecular simulations.
Jose Onuchic - Theoretical biological physics, protein folding and dynamics, electron transfer in biology, chemical reactions in complex biological systems // theoretical and computational methods, simulation of biological systems.
Arthur Palmer - Structural biology, protein dynamics and folding // NMR spectroscpy, fluorescence spectroscopy, molecular dynamics simulations.
Heinrich Roder - Protein folding, misfolding and amyloid formation, protein structure and dynamics // NMR, fluorescence, kinetics, rapid mixing.
Steven Schwartz - Quantum, Classical, and Statistical mechanical studies of reactions in biological systems, Rate theories of chemical processes, Theoretical studies of enzyme mechanisms, Protein dynamics and biological processes, Importance sampling in biological simulation, Mathematical modeling of complex systems.
Jill Trewhella - Protein structure, calcium binding proteins, second messenger signaling, kinase regulation, muscle regulatory proteins // small-angle scattering, diffraction.
Gregory Voth - Theory and modeling of proteins, biomembranes, protein-membrane interactions, protein and peptide self-assembly, nucleic acids, and the cytoskeleton // theory, modeling, molecular dynamics simulation, multi-scale theory and modeling.
SECTION II: CHANNELS, ELECTROPHYSIOLOGY, RECEPTORS
Eduardo Perozo, Associate Editor - Voltage-dependent ion channels, mechanosensitive channels, membrane protein structure, membrane protein conformational changes, protein-lipid interactions // spin labeling, EPR spectroscopy, voltage-clamp, patch clamp, cut-open oocyte, planar lipid bilayers, membrane protein reconstitution.
Richard Aldrich - Ion Channels, Excitable Membranes, Conformational Changes // voltage clamp, patch clamp, electrophysiology.
Francisco Bezanilla - Ion channel structure-function, gating currents, ionic currents,single channels, fluorescence spectroscopy applied to structure-function studies, kinetic modelling.
Robert Chow - Exocytosis, Synaptic transmission, SNARE proteins; membrane capacitance measurements, carbon-fiber amperometry, and total internal reflection fluorescence microscopy.
David Eisner - Cardiac muscle, cardiac excitation contraction coupling, cardiac calcium signalling, calcium transport // voltage clamp, fluourescence.
Dorothy Hanck - Channels: voltage gated, gap junctional, other types as well // electrophysiology, fluorescence, modeling.
Toshinori Hoshi - Ion channel gating, potassium channels, protein oxidation, aging // electrophysiology, patch-clamp.
Tzyh-Chang Hwang - Single-channel recordings, ion channel gating kinetics and energetics, ion channel structure // function relationship, ion channel permeation mechanisms, membrane protein trafficking, membrane transporters and membrane signaling.
Peter Jordan - Ion Channels, water channels, lipid-channel interaction // Theoretical methods, Molecular dynamics, Monte Carlo, Simulations, Kinetic modeling, electrostatic modeling.
Kenton Swartz - Structure and gating mechanisms of voltage-activated ion channels, interaction of protein toxins with membranes and ion channels, lipid-channel interactions, structure and gating mechanisms of P2X receptor channels // Electrophysiology, protein biochemistry, mutagenesis and site-directed labeling, fluorescence spectroscopy.
David Weiss - Ion channel structure/function, ligand-activated ion channels, ion channel kinetics, ion channel gating kinetics, ion channel permeation/selectivity // fluorescence spectroscopy, radioactivate ligand binding, site-directed mutagenesis, patch clamp, two-electrode voltage clamp.
Jian Yang - Ion channel structure, function and regulation, voltage-gated Ca2+ and inward rectifier K+ channels // patch-clamp, site-directed mutagenesis, heterologous expression, x-ray crystallography.
SECTION III: CELL BIOPHYSICS
Michael Edidin, Associate Editor - Cells, Immunology, Membrane Domains, Lipid bilayers, Membrane proteins, endocytosis // Fluorescence microscopy, Confocal, Total internal reflection, Conventional FRET (fluorescence resonance energy transfer), Lateral diffusion measurements (FRAP, collisional quenching, other).
George Barisas - Cell surface dynamics, cell surface organization, molecular rotation, receptor aggregation, single-molecule phenomena // fluorescence, phosphorescence, lateral diffusion (FRAP, single-particle tracking, etc.), rotational diffusion (time-resolved luminescence and depletion anisotropies), optical microscopy (fluorescence, confocal, TIR), nanoparticle probes.
Arup Chakraborty - T cell biology, cell signaling, immunology, membrane dynamics and thermodynamics // Computational and theoretical statistical mechanics.
Alberto Diaspro - Cell biophysics, cell trafficking, cell intercations with nanostructured systems, chromatin-DNA, visible fluorescent protein photophysics //Multiphoton, confocal and computational optical sectioning 3D fluorescence microscopy, three-dimensional optical imaging, image deconvolution, scanning probe microscopy (AFM, SNOM), single molecule microscopy, F techniques: FRAP, FRET, FLIM, light scattering and differential polarization light scattering.
Marileen Dogterom - Microtubule dynamics and organization, Cytoskeletal force generation, Membrane tubes // Optical tweezers, Microfabrication, Video-microscopy, Modeling.
R. Brian Dyer - Protein folding; Protein structure, dynamics and function; electron and proton transfer in proteins // Laser and optical spectroscopies, Vibrational spectroscopies (IR and Raman); time-resolved methods; nonlinear spectroscopies, spectroscopic imaging.
Feng Gai - Protein folding, protein and peptide conformational dynamics, aggregation, peptide-membrane interactions, photo-initiated events // Static and time-resolved infrared and fluorescence spectroscopies, single-molecule fluorescence spectroscopy and microscopy, ultrafast optical methods, surface plasmon resonance spectroscopy.
Enrico Gratton - Spectroscopy, fluorescence microscopy, Fluorescence Correlation Spectroscopy (FCS), 2-photon excitation fluorescence.
Marilyn Gunner - Electron and proton transfer reactions, photosynthesis, electrostatics, calculations of pKs in proteins, enzyme reaction thermodynamics // time resolved optical spectroscopy, reaction kinetics at cryogenic temperatures, continuum electrostatics, Monte Carlo, molecular mechanics.
Akihiro Kusumi - Single molecule cell biology, cell signaling, membrane domains, dynamic molecular assembly in/on the membrane, membrane skeleton, diffusion processes in the membrane, membrane traffic // single fluorescence molecule detection in live cells, single particle tracking, optical tweezers, optical probe techniques, transient anisotroy decay, FRAP, FRET, FLIM.
Janos Lanyi - Bacteriorhodopsin, halorhodopsin, sensory rhodopsin, retinal proteins, ion pumps // time-resolved spectroscopy in the visible, low temperature spectroscopy, time-resolved spectroscopy in the infrared, membrane protein crystallography.
Jennifer Linderman - Receptor dynamics, signal transduction, G protein coupled receptors, cell and tissue engineering // cell and reaction pathway modeling, computer simulations, flow cytometry.
Stuart Lindsay - Scanning Probe Microscopy, single molecule measurements, force spectroscopy // microscopy of DNA and DNA-protein complexes, chromatin structure and function, electronic properties of molecules.
David Piston - Cell biophysics, exocytosis, metabolic regulation protein-protein interactions // fluorescence, microscopy-fluorescence/luminescent, FLIM, FRET-multiphoton, confocal, non-linear optical, scanning near-field microscopy.
Thomas Schmidt - Membrane biophysics, mobility of membrane components, cell signaling // linear and nonlinear microscopy, single-molecule techniques, AFM.
Petra Schwille - Cell and Membrane Biophysics, Single Molecule Methods, Fluorescence Correlation Spectroscopy, Lipid-Protein Interactions, Membrane Domains, FRET Systems, Two-Photon Excitation, Micro- and Nanofluidics, Giant Unilamellar Vesicles, Atomic Force Microscopy, Fluorescent Proteins.
Denis Wirtz - Cell microrheology, cytoskeleton dynamics, cell motility and migration, cell polarization, cell adhesion, cell-virus interactions, protein trafficking, nucleus architecture and dynanics // single-molecule detection, single-molecule force spectroscopy, AFM, particle tracking methods, magnetic and optical probes, live-cell imaging, cell-mechanics methods, FRAP, FLIP, FRET
SECTION IV: MEMBRANES
Anthony Watts, Associate Editor - Biomembrane structure, protein-lipid interactions, ligand-receptor interactions, photoreceptors // solid state NMR, spin label ESR, membrane protein reconstitutions.
Paul Axelsen - Molecular recognition, structure-based molecular design, protein lipid interactions, lipid membranes // infrared and fluorescence spectroscopy, molecular dynamics simulation, mass spectrometry.
Betty Gaffney - Paramagnetic proteins, metalloprotein, protein radicals, mechanism of iron and manganese enzymes, unsaturated lipids and eicosanoids, spin labels, xenon, magnetism in biology // EPR/ESR spectroscopy, simulation of metalloprotein EPR spectra, characterization of protein radicals, spin label techniques.
Mark Girvin - Bioenergetics, membrane protein structure, ATP synthase, multidrug resistance transporters // solution NMR, membrane protein expression, membrane protein purification, membrane protein reconstitution.
Helmut Grubmuller - Theory and simulation of protein dynamics/function and of single molecule experiments, molecular dynamics algorithms, F-ATPase, aquaglyceroporins, lipid bilayers // theoritical physics, molecular dynamics simulations, QM/MM hybrid methods, statistical mechanics, parallel computing.
Peter Hinterdorfer - Molecular Recognition, Protein/Ligand Interaction, Cell Biophysics, Cell Adhesion and Mechanics, Cell and Model Membranes, Protein/DNA/RNA Mechanics // Single Molecule Experiments, Single Molecule Microscopy, Atomic Force Microscopy Imaging, Force Spectroscopy.
Thomas McIntosh - Membrane structure, peptide-lipid interactions, model membranes, membrane rafts // X-ray diffraction.
Klaus Schulten - Molecular modeling, metabolic and signaling, networks-theory, membrane protein function-theory, molecular motors-theory, ATP synthase and related proteins-theory, photoreceptors-theory, photosynthesis-theory, mechanobiology, bacteriorhodopsin, cell biophysics, multi-scale methods, quantum dynamics, reaction-diffusion, rate models, statistical physics, general physics, general theory.
Lukas Tamm - Biomembrane structure and dynamics, protein-lipid interactions, membrane protein structure, membrane protein folding, membrane fusion // NMR, fluorescence, microscopy, supported membranes.
Peter Tieleman - Membrane protein structure and dynamics, transporters, ion channels, lipid structure and dynamics // computer simulation, molecular modeling, continuum models.
David D. Thomas - Muscle and membrane proteins, structural and functional dynamics, myosin, actin, SERCA, phospholamban // site-directed spectroscopic labeling, spin label EPR, fluorescence, phosphorescence, NMR.
Joshua Zimmerberg -
SECTION V: BIOLOGICAL SYSTEMS, CELLULAR PROCESSES, MULTICELLULAR DYNAMICS
Herbert Levine, Associate Editor - Calcium signaling, multicellular aggregation, in vitro evolution // reaction-diffusion equations, nonlinear dynamics, computational approaches to cell biology.
Gaudenz Danuser - Biophysics of cell motility, mitosis, endocytosis, cytoskeleton mechanics, cytoskeleton related signaling // light microscopy, image analysis, computational modeling of mechanical networks, computational modeling of reaction-diffusion-convection networks).
Elliot Elson - Tissue constructs and tissue mechanics, cell mechanics and motility, macromolecular conformational fluctuations, molecular transport on cell surfaces and in cytoplasm//fluorescence correlation spectroscopy, fluorescence photobleaching recovery, single particle tracking, measurements of cellular and tissue construct mechanical properties.
Jason Haugh - Cell signaling mechanisms, signal transduction pathways, receptor dynamics, cell migration and chemotaxis, theoretical/computational biology of cellular processes // biochemical measurements, live-cell fluorescence microscopy, TIRF microscopy, kinetic and spatial modeling/analysis, transport phenomena.
Costas Maranas - Computational protein design, metabolic engineering, topological analysis of biological networks // mathematical optimization techniques, network analysis.
Gerhard Marriott - Molecular basis of cell motility and muscle contraction Protein structure and dynamics Actin, cytoskeleton proteins and molecular motors Cell signaling // Design, synthesis and application of optical probes Genetically encoded proteins Otical imaging techniques e.g. FRAP, FRET, FLIM. Fluorescence and phosphorescence spectroscopy Nanobiotechnology
Alexander Mogilner - Cell motility, cell division, mitosis, molecular motors (theory), mathematical models in cell biology, theoretical biophysics of cytoskeleton // mathematical modeling(differential equations and numerical simulations).
Ian Parker - Calcium signaling, IP3 signaling, single-channel imaging, immunoimaging // confocal and multi-photon microscopy, TIRFM, caged compounds, electrophysiology.
Arthur Sherman - Insulin secretion, calcium oscillations, bursting electrical activity, neuroendocrine cells, neural modeling // Ordinary, partial, and stochastic differential equations (numerical and analytical techniques), dynamical systems, bifurcation theory.
Michael Stern - Calcium Signaling,Calcium Waves,Excitation-Contraction Coupling,Fluctuation Analysis,Markov processes,Light Scattering & Coherent optics,Ryanodine Receptors,cellular electrophysiology//mathematical modeling,computer simulation,stochastic/Monte Carlo methods,calcium imaging,whole-cell voltage clamp,confocal microscopy.
Rick Waugh - Physical properties of bilayer membranes; erythrocyte membrane structure and function, cell (especially leukocyte) adhesion, cytoskeletal mechanics, mechanical properties of cells and cell membranes // Micropipette manipulation, fluorescence microscopy, video microscopy.
SECTION VI: MUSCLE, MOTILITY AND MOTOR
PROTEINS
Yale Goldman, Associate Editor -
Christopher Berger - Myosin, kinesin, muscle contraction, intracellular transport, molecular motors // fluorescence and phosphorescence spectroscopy (e.g. FRET, tyrptophan fluorescence, LRET, PET, anisotropy/polarization), time-resolved spectroscopy, single molecule spectroscopy (e.g. FRET, FCS), single molecule mechanics (e.g. optical tweezers), transient kinetics.
Cristobal dos Remedios - Cytoskeletal proteins, particularly actin and actin-binding proteins (cofilin, gelsolin, DNase I, thymosin beta 4) but not microtubules and their motor proteins, FRET techniques with protein-protein interaction in vitro and with whole cell cytoskeletal proteins, Cardiac muscle, particularly human heart failure, structure, hypertrophic cardiomyopathy, dilated cardiomyopathies, familial cardiomyopathies, Gene arrays and transcriptomics, protein arrays and proteomics, cell arrays and cellomics, Water pollution, particularly bioassays of chemical toxicants in drinking water, waste water, ground water, Leukocytes, particularly Cluster of Differentiation (CD) antibodies and CD antigen expression, associated with inflammation, autoimmunity, malignancy.
Susan P, Gilbert - Molecular motors, kinesins, cytoskeleton, cell motility//presteady-state kinetics, biochemistry, fluorescence microscopy.
Taekjip Ha - DNA-protein and protein-protein interactions, protein and RNA folding, membrane biophysics, fluorescence microscopy of biological systems, single molecule spectroscopy and manipulations, biologically inspired nano-mechanical devices, RecA // fluorescence, microscopy, spectroscopy, single particle tracking, optical tweezers, FRAP, FRET.
David Hackney - Energy coupling in ATPases, mechanism and regulation of motors proteins // single turnover reactions (stopped flow and quenched flow), fluorescence (to monitor binding and conformational changes), isotopic exchange reactions, motility assays including single molecule studies.
Hideo Higuchi - Single molecules, molecular motors (myosin, kinesin and dynein), muscle contraction, cell motility // optical microscope,imaging,fluorescence dyes.
Malcolm Irving - Skeletal muscle contraction; regulation of skeletal muscle by calcium; skeletal muscle myosin; troponin in skeletal muscle // X-ray fiber diffraction, polarised fluorescence, demembranated single muscle fibers, muscle mechanics.
Shin'ichi Ishiwata - Single-molecule mechanics, Molecular motors (myosin, kinesin family), Muscle contraction and regulation (Skeletal and cardiac muscle fibers and fibrils), Dynamics of actin filament // Optical microscopy, Optical tweezers, Microphysiology, Structural and functional reconstitution.
E. Michael Ostap - Molecular motors, myosin biochemistry and mechanics, cytoskeleton, cell motility // transient kinetics, live cell microscopy, protein-protein interactions, protein-membrane interactions.
Kuda Ranatunga - Muscle mechanics, contraction and function, force-velocity relation, force generation, crossbridge cycle and kinetics, temperature dependence, pressure effects // intact muscle recording, skinned fiber recording, laser temperature-jumps, length perturbation, laser diffraction, kinetic modeling.
Claudia Veigel -
Leepo Yu - Muscle structure, muscle physiology, molecular motors, muscle mechanics, cardiac muscle contractility.
David Piston, Chair
Gunjan Agarwal
Mordecai Blaustein, ex officio
Eric Jakobsson
Diane Papazian
Frederick Sachs
Da Nang Wang
Copyright © 2008 by the Biophysical Society.
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